My work focuses on understanding how daily biological rhythms function and interact in the context of disease and disease transmission, particularly in insect-transmitted diseases.
Biological clocks (“circadian rhythms”) underlie diverse biological processes including detoxification, behaviour, and sensory processes. These rhythms allow organisms to adjust to an environment that can change dramatically over the 24 hour day. Disruption (such as “jet-lag”) of these rhythms has serious consequences to the organism; and there are, for example, time-of-day specific effects to drug efficacy and insecticide toxicity.
I work on understanding how daily biological rhythms function and interact in the context of disease and disease transmission, particularly in insect-transmitted diseases; as well as on the basic physiology and behaviour of the mosquito. Disruption or exploitation of natural rhythms in the host, vector, or even pathogen could lead to novel disease interventions.
You can read more about Samuel's research on his website www.samrund.com.
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Rund, S.S.C., O’Donnell, A.J., Gentile, J.E. & Reece, S.E. (2016) Daily Rhythms in Mosquitoes and Their Consequences for Malaria Transmission. Insects, 7, 14.
Leming M.T., Rund S.S.C., Behura S.K., Duffield G.E. and O’Tousa J.E. (2014) A database of circadian and diel rhythmic gene expression in the yellow fever mosquito Aedes aegypti. BMC Genomics 2014, 15:1128.
Balmert N.J., Rund S.S.C., Ghazi J.P._, Zhou, P., and Duffield G.E. (2014) Time-of-day specific changes in metabolic detoxification and insecticide resistance in Anopheles gambiae mosquitoes. Journal of Insect Physiology 64:30-39.
Rund S.S.C.#, Bonar N.A.#, Champion M.C., Ghazi J.P._, Houk C.H., Leming M.L., Syed Z., and Duffield G.E. (2013) Daily rhythms in antennal protein and electroantennogram sensitivity in the Anopheles gambiae malaria mosquito. Scientific Reports 3:2494. #Co-first author
This paper was featured on the AAAS Science Update podcast, Sept 20, 2013 This paper was featured on The Scientist’s, “Speaking of Science” feature, Oct. 1, 2013
Keating J.A., Bhattacharya D, Rund S.S.C., Hoover S., Dasgupta R., Lee S.J., Duffield, G.E., and Striker, R. (2013) Mosquito protein kinase G phosphorylates flavivirus NS5 and alters flight behavior in Aedes aegypti and Anopheles gambiae. Vector-Bourne and Zoonotic Diseases 13:590-600.
Rund S.S.C., Gentile, J.E., and Duffield, J.G. (2013) Extensive circadian and light regulation of the transcriptome in the malaria mosquito Anopheles gambiae. BMC Genomics 14: 218. Supplementary information.
Rund S.S.C., Lee S.J., Bush B.R., Duffield, G.E. (2012) Strain- and sex-specific differences in daily flight activity and the circadian clock of Anopheles gambiae mosquitoes. Journal of Insect Physiology. 58: 1609-1619.
Gentile, J.E., Davis, GJ, and Rund, S.S.C. (2012) Verifying agent-based models with steady-state analysis. Computational & Mathematical Organization Theory18: 404-418.
Rund, S.S.C., Hou, T.Y., Ward, S.M., Collins, F.H. and Duffield, G.E. (2011) Genome-wide profiling of diel and circadian gene expression of the malaria vector Anopheles gambiae. Proceedings of the National Academy of Sciences USA 108 (32): E421-E430. Supplementary information.
This paper was featured in the International Pest Control magazine. September/October 2011, page 243. Link (requires subscription). A figure from this paper is reproduced in the 3rd edition of Animal Physiology (Hill, Wyse, and Anderson, 2012).
Gentile, J.E. & Rund, S.S.C. (2011) A framework for modeling genetically-aware mosquito vectors for sterile insect technique. International Journal of Agent Technologies and Systems. 3 (3): 49-65.
Shin J, Epperson K, Yanjanin NM, Albus J, Borgenheimer L, . . . Rund, S., . . . et al. (2011) Defining Natural History: Assessment of the Ability of College Students to Aid in Characterizing Clinical Progression of Niemann-Pick Disease, Type C. PLoS ONE 6(10): e23666.
2014 - present
University of Edinburgh, UK Postdoctoral Fellow
2008 - 2014
University of Notre Dame, USA PhD Biology Vector and Circadian Biology
2004 - 2008
DePauw University, USA Bachelor of Arts Major: Biochemistry, Minor: Computer Science Science Research Fellow (Honors Program)